Research Foundation Research Articles

Systematic analysis of ocular features and responses of cultured spotted wolffish (Anarhichas minor).

A better understanding of unique anatomical and functional features of the visual systems of teleost fish could provide key knowledge on how these systems influence the health and survival of these animals in both wild and culture environments. We took a systematic approach to assess some of the visual systems of spotted wolffish (Anarhichas minor), a species of increasing importance in North Atlantic aquaculture initiatives. The lumpfish (Cyclopterus lumpus) was included in these studies in a comparative manner to provide reference. Histology, light and electron microscopy were used to study the spatial distribution and occurrence of cone photoreceptor cells and the nature of the retinal tissues, while immunohistochemistry was used to explore the expression patterns of two photoreceptor markers, XAP-1 and XAP-2, in both species. A marine bacterial infection paradigm in lumpfish was used to assess how host-pathogen responses might impact the expression of these photoreceptor markers in these animals. We define a basic photoreceptor mosaic and present an ultrastructural to macroscopic geographical configuration of the retinal pigment tissues in both animals. Photoreceptor markers XAP-1 and XAP-2 have novel distribution patterns in spotted wolffish and lumpfish retinas, and exogenous pathogenic influences can affect the normal expression pattern of XAP-1 in lumpfish. Live tank-side ophthalmoscopy and spectral domain optical coherence tomography (SD-OCT) revealed that normal cultured spotted wolffish display novel variations in the shape of the retinal tissue. These two complementary imaging findings suggest that spotted wolffish harbour unique ocular features not yet described in marine teleosts and that visual function might involve specific retinal tissue shape dynamics in these animals. Finally, extensive endogenous biofluorescence is present in the retinal tissues of both animals, which raises questions about how these animals might use retinal tissue in novel ways for visual perception and/or communication. This work advances fundamental knowledge on the visual systems of two economically important but now threatened North Atlantic teleosts and provides a basic foundation for further research on the visual systems of these animals in health versus disease settings. This work could also be useful for understanding and optimizing the health and welfare of lumpfish and spotted wolffish in aquaculture towards a one health or integrative perspective.

Dementia Knowledge in Chinese Newspapers (2005-2020): A Topic Modeling Analysis.

How public policies convey dementia is an important source of the public's understanding of dementia, and newspapers are critical to depicting and disseminating this information to the public. The present study used topic modeling strategies to analyze Chinese newspaper portrayals of dementia from 2005 to 2020 to trace changes in key areas of dementia knowledge in relevant policies. Using WiseNews, the largest Chinese media database, we chose 45 newspapers from mainland China and identified 12,719 articles related to dementia. Using latent Dirichlet allocation (LDA), we performed a topic modeling analysis and identified the six most prevalent topics on dementia across articles: lifestyle recommendations, neighborhood life, foundational scientific research, celebrity and media portrayals, dementia caregiving, and pharmaceutical innovations - all related to the dementia knowledge scale's four dimensions. Findings suggest a steady increase in the number of articles on dementia caregiving and a decline in lifestyle recommendations from 2005 to 2020. However, newspapers continued to stigmatize aging by regularly co-depicting dementia and old age and by using biased terminology. Among the first to investigate dementia's portrayals in mainland Chinese newspapers, this study illuminates the need for expanding mass media campaigns to raise the country's dementia knowledge to foster a dementia-inclusive society.

Grounding Fault Diagnosis of Running Rails Based on a Multi-scale One-Dimensional Convolutional Neural Network in a DC Subway System

AbstractRunning rails are the return conductors of the traction current in DC subway systems, which should be insulated from the earth. Due to the large length of the line, as well as the humidity and metal dust in the tunnel, grounding fault of the running rails usually occurs, which will increase stray current (SC) leakage and endanger power supply safety. In this paper, a method of grounding fault diagnosis of running rails based on a multi-scale one-dimensional convolutional neural network (MS-1DCNN) is proposed. Firstly, a platform for the dynamic distribution of SC and rail potential (RP) with grounding faults existing in the running rails is established, which generates the dynamic RP data with various grounding faults. Secondly, a grounding fault diagnostic method of running rails based on MS-1DCNN is proposed, so as to realize the effective identification of ground fault types in subway systems. Thirdly, with the proposed diagnostic method, the datasets under two operating conditions of a single train and two trains are tested; a comparison test between MS-1DCNN and the 1D convolutional neural network (1DCNN) is carried out, and the effectiveness of the proposed method is verified. Results demonstrate that the proposed model can significantly improve the ground fault diagnostic accuracy of running rails. The dynamic RP simulation platform for trains established in this paper lays a theoretical foundation for the grounding fault research of running rail. Moreover, the deep learning method is proposed for the first time to diagnose the grounding fault of running rail, and the high diagnostic accuracy is obtained, which is of great significance for the safe and stable operation of the subway line.

Primary omental smooth muscle tumor in an adult male: a diagnostic dilemma for leiomyoma: a case report

BackgroundThe greater omentum comprises peritoneal, adipose, vascular, and lymphoid tissues. Most omental malignancies are metastatic tumors, and the incidence of primary tumors is rare. We report on a prior omental smooth muscle tumor case in an adult male patient.Case presentationA 54-year-old Japanese male patient with no relevant medical history was diagnosed with an abdominal mass during a routine medical checkup. Subsequent contrast-enhanced computed tomography revealed a mass of approximately 3 cm in size in the greater omentum, and a laparotomy was performed. A 27 × 25 × 20 mm raised lesion was found in the omentum. Microscopically, spindle cells were observed and arranged in whorls and fascicles. Individual tumor cells had short spindle-shaped nuclei with slightly increased chromatin and were characterized by a slightly eosinophilic, spindle-shaped cytoplasm. The mitotic count was less than 1 per 50 high-power fields. The tumor cells showed positive immunoreactivity for α smooth muscle actin, HHF35, and desmin on immunohistochemical examination. The Ki-67 labeling index using the average method was 1.76% (261/14806). No immunoreactivity was observed for any of the other tested markers. We considered leiomyoma owing to a lack of malignant findings. However, primary omental leiomyoma has rarely been reported, and it can be difficult to completely rule out the malignant potential of smooth muscle tumors in soft tissues. Our patient was decisively diagnosed with a primary omental smooth muscle tumor considering leiomyoma. Consequently, the patient did not undergo additional adjuvant therapy and was followed up. The patient was satisfied with treatment and showed neither recurrence nor metastasis at the 13-month postoperative follow-up.Discussion and conclusionWe encountered a primary smooth muscle tumor of the greater omentum with no histological findings suggestive of malignancy in an adult male patient. However, omental smooth muscle tumors are extremely difficult to define as benign, requiring careful diagnosis. Further case reports with long-term follow-up and case series are required to determine whether a true omental benign smooth muscle tumor (leiomyoma) exists. In addition, proper interpretation of the Ki-67 labeling index should be established. This case study is a foundation for future research.

Characteristics and utility of high-resolution optical coherence microscopy images of endocervical canal lesions.

To investigate optical coherence microscopy (OCM) imaging features and the application value of these high-resolution images for identifying endocervical canal lesions (ECLs), which is a clinical dilemma in cervical cancer screening programs. In total, 520 OCM images were obtained by scanning the cervical canal lesions with an ultra-high-resolution OCM system (204 specimens from 73 patients). The OCM morphologic characteristics of ECLs were observed and summarized, and then 3 researchers performed a diagnostic test of OCM images of cervical canal lesions. The accuracy, sensitivity, specificity, positive predictive value, negative predictive value, 95% confidence interval of each parameter, and interinvestigator agreement (κ) were calculated. Normal endocervix, cysts, squamous metaplasia, high-grade squamous intraepithelial lesions involving glands, and invasive carcinoma had distinct OCM characteristics, which correlated well with corresponding H&E histologic sections. The accuracy, sensitivity, and specificity of the 3 researchers were 90.6%, 89.3% (95% CI, 86.5%-91.7%) and 91.6% (95% CI, 89.2%-93.5%), respectively. The positive predictive value was 90.1% (95% CI, 87.3%-92.4%), and the negative predictive value was 90.9% (95% CI, 88.5%-92.9%), with almost perfect agreement (κ = 0.874). The application of the OCM system in cervical canal lesions is feasible and could help improve detection of occult ECLs in cervical cancer screening programs. This study lays the foundation for further research on OCM in cervical canal lesions in vivo, which also has a potential impact on projecting pathologic evaluation beyond what is currently possible, perhaps globally.

Utilizing chitosan and titanium dioxide nanomaterials and their nanocomposites for improving the growth and biochemical responses of Sorghum bicolor (L.)

It is imperative to comprehensively assess the impact of nano-based technologies on plants and ensure their safety before integrating them into agricultural practices. In this context, the present study demonstrates the effect of nanosized chitosan (CS), titanium dioxide (TiO2), and CS/TiO2 nanocomposites (NCPs) on Sorghum bicolor (L.) Moench, the fifth most important grain crop globally. The nanomaterials were chemically synthesized and characterized in terms of size, surface morphology, structure, functional groups, and hydrodynamic diameter. S. bicolor plants were cultivated in soil spiked with these nanomaterials at two different concentrations (100 and 200 ppm) for up to 30 days. Compared to control plants, all three nanomaterials stimulated the growth of S. bicolor by 3-23% and enhancednutrient uptake. Additionally, they increased the concentrations of chlorophyll (35-94%), starch (13-19%), cellulose (12-56%), and protein (3-119%) in the shoots, while reducing the malondialdehyde (MDA) content. However, elevated MDA levels in the roots of plants treated with TiO2 nanoparticles and CS/TiO2 NCPs indicated that mild oxidative stress had occurred, which the plant managed to counteract by enhancing antioxidant enzyme activities. The findings of this study confirm the safety of using these nanomaterials and provide a foundation for future research aimed at enhancing the growth, adaptability, and yield of S. bicolor.

Preponderant Relationships: Violent Crime, Premises Security Litigation, and Low-Income Housing

ABSTRACT This paper advances knowledge of the ways in which criminological research can assist the courts in rendering legal decisions. To do so, we examine case examples from premises security litigation involving low-income housing developments. We describe the investigative tasks of a premises security lawsuit, address the challenges of examining and explaining a criminal assault, and show how criminological scholarship can point to the importance of place management in suppressing or facilitating crime in low-income housing developments. We examine three preponderant relationships – offender and victim, security standards and proximate causation, and place management and crime opportunities – to provide insight into the translation of criminological knowledge into actionable legal outcomes. We address the nexus of environmental criminology and premises security litigation to strengthen the scientific foundation of criminological research and improve the quality of forensic social scientific research in the legal system.

A Dataset for Evaluating Contextualized Representation of Biomedical Concepts in Language Models

Due to the complexity of the biomedical domain, the ability to capture semantically meaningful representations of terms in context is a long-standing challenge. Despite important progress in the past years, no evaluation benchmark has been developed to evaluate how well language models represent biomedical concepts according to their corresponding context. Inspired by the Word-in-Context (WiC) benchmark, in which word sense disambiguation is reformulated as a binary classification task, we propose a novel dataset, BioWiC, to evaluate the ability of language models to encode biomedical terms in context. BioWiC comprises 20’156 instances, covering over 7’400 unique biomedical terms, making it the largest WiC dataset in the biomedical domain. We evaluate BioWiC both intrinsically and extrinsically and show that it could be used as a reliable benchmark for evaluating context-dependent embeddings in biomedical corpora. In addition, we conduct several experiments using a variety of discriminative and generative large language models to establish robust baselines that can serve as a foundation for future research.

Antenatal depression among pregnant mothers in Afghanistan: A cross-sectional study

BackgroundApproximately one in five pregnant women experience antenatal depression globally. The purpose of the present study was to estimate the prevalence of antenatal depression and explore its relationship between various demographic variables, recent sexual engagement, and recent adverse life events among pregnant Afghan women.MethodsA cross-sectional survey study was carried out between January, 2023 and April 2023 among 460 women aged 15–45 years who were recruited using convenience sampling from Herat province (Afghanistan). Logistic regression models were utilized to explore the relationship between antenatal depression and socio-demographic characteristics among the participants.ResultsThe prevalence of antenatal depression symptoms was 78.5%. Multiple regression analysis indicated that antenatal depression was significantly associated with (i) being aged 30–45 years (AOR: 4.216, 95% CI: 1.868–9.515, p = .001), (ii) being of low economic status (AOR:2.102, 95% CI: 1.051–4.202, p = .036), (iii) not being employed (AOR: 2.445, 95% CI:1.189–5.025, p = .015), (iv) not having had sex during the past seven days (AOR: 2.335, 95% CI: 1.427–3.822, p = .001), and (v) not experiencing a traumatic event during the past month (AOR:0.263, 95% CI: 0.139–0.495, p < .001).ConclusionThe present study provides insight into the factors associated with the high prevalence of antenatal depression among pregnant Afghan women (e.g., demographic variables, recent adverse life events, and recent sexual engagement). It highlights the urgency of addressing antenatal depression in Afghanistan and provides a foundation for future research and interventions aimed at improving the mental health and well-being of pregnant women in the Afghan context.

Obstetric and perinatal outcomes in women with previous breast cancer: a nationwide study of singleton births 1973–2017

Abstract STUDY QUESTION What are the obstetric and perinatal outcomes in births to breast cancer survivors compared to women without previous breast cancer? SUMMARY ANSWER Women who conceived during the first 2 years following a breast cancer diagnosis had a higher risk for preterm birth, induced delivery and caesarean section, while no increased risks were observed in births conceived later than 2 years after breast cancer diagnosis. WHAT IS KNOWN ALREADY A recent meta-analysis found higher risks of caesarean section, preterm birth, low birthweight, and small for gestational age in pregnancies among breast cancer survivors. Less is known about rarer outcomes such as pre-eclampsia or congenital malformations. STUDY DESIGN, SIZE, DURATION We conducted a population-based matched cohort study including all breast cancer survivors who gave birth to singletons 1973–2017 in Sweden, identified through linkage between the Swedish Cancer Register, the Medical Birth Register, and the National Quality Register for Breast Cancer. PARTICIPANTS/MATERIALS, SETTINGS, METHODS Each birth following breast cancer (n = 926) was matched by maternal age at delivery, parity and calendar year at delivery to 100 births in a comparator cohort of women (n = 92,490). Conditional logistic and multinomial regression models estimated relative risks (RR) with 95% CI. Subgroup analyses by time since diagnosis and type of treatment were performed. MAIN RESULTS AND THE ROLE OF CHANCE Previous breast cancer was associated with higher risks of induced delivery (RR; 1.3, 1.0–1.6), very preterm birth (RR; 1.8, 1.1–3.0) and planned preterm birth (RR; 1.6, 1.0–2.4). Women that conceived within 1 year after breast cancer diagnosis had higher risks of caesarean section (RR; 1.7, 1.0–2.7), very preterm birth (RR; 5.3, 1.9–14.8) and low birthweight (RR; 2.7, 1.4–5.2), while the risks of induced delivery (RR; 1.8, 1.1–2.9), moderately preterm birth (RR; 2.1, 1.2–3.7) and planned preterm birth (RR; 2.5, 1.1–5.7) were higher in women that conceived during the second year after diagnosis. Women that conceived later than 2 years after breast cancer diagnosis had similar obstetric risks to their comparators. LIMITATIONS, REASONS FOR CAUTION As information on end date of treatment was unavailable, time between the date of diagnosis and conception was used as a proxy, which does not fully capture the effect of time since end of treatment. In addition, treatments and clinical recommendations have changed over the long study period, which may impact childbearing patterns in breast cancer survivors. WIDER IMPLICATIONS OF THE FINDINGS Risks of adverse obstetric outcomes in breast cancer survivors were confined to births conceived within 2 years of diagnosis. As family building holds significance for numerous young breast cancer patients, these findings are particularly important to inform both breast cancer survivors and clinicians about future reproductive outcomes. STUDY FUNDING/COMPETING INTEREST(S) This work was supported by the Swedish Cancer Society (grant number 22-2044 Pj Anna Johansson), Karolinska Institutet Foundations (grant number: 2022-01696 Frida Lundberg, 2022-01559 Anna Johansson), and the Swedish Research Council (grant number: 2021–01657 Anna Johansson). Kenny Rodriguez-Wallberg is supported by grants from the Swedish Cancer society (20 0170 F) and the Radiumhemmets Research Foundations for clinical researchers 2020-2026. The authors declare that they have no conflicts of interests. TRIAL REGISTRATION NUMBER N/A.

37 Key learnings from the improving pig survivability project

Abstract The Improving Pig Survivability Project has completed 5 yr encompassing research, education, and extension with the goal of reducing overall mortality in the U.S. commercial swine industry. The project is funded by National Pork Board and Foundation for Food and Agriculture Research, and continues through 2026. Team members represent institutions including Iowa State University, Kansas State University, and Purdue University. The project is guided by an advisory board consisting of US swine producers and allied industry partners. Research efforts seek to identify factors contributing to swine mortality in commercial production, and to develop strategies and information that can be utilized to reduce mortality and maximize pig survivability. Key economic findings include the first publicly available economic tool for swine producers to input their specific production information and costs, creating a farm level specific cost of mortality for both the breeding herd and post-weaning to market. Key strategies found to reduce sow mortality include: understanding late gestation body condition as thin sows in late gestation are more likely to prolapse compared with normal or overweight sows; Early intervention to monitor and treat lameness resulted in 25.4% relative reduction in annualized sow mortality in commercial settings tested; Feeding sows four 1.5-pound meals reduced farrowing assistance and reduced piglet deaths compared with ad libitum intake for 3 to 5 d before farrowing; perineal score, genetics, and microbiome risk factors for pelvic organ prolapse were identified. Key strategies found to reduce pre-weaning mortality include: colostrum should be 300 to 350 g per piglet, and a milky cheese addition during enrichment period. Key strategies found to reduce wean to finish mortality include: whole-herd analysis of 2,568 WTF closeouts revealed sow farm parameters associated with improved livability were sow farm health status and productivity associated with lower WTF mortality; Increased mortality was associated with Streptococcus suis, Glaeserella parasuis, PRRSv, Mycoplasma hyopneumoniae and PEDv; early maturing duroc sired pigs had reduced stress, greater feed intake, decreased % losing body weight post weaning, and greater gain during the nursery period; enrichment cubes to pigs post-weaning reduced the percentage losing body weight after weaning; feeding large pellet creep feed in lactation improved nursery pig growth and decreased fallout rates; mat feeding reduced mortality and removals; sensory attractant powder before and after weaning reduced percentage that lost body weight the first 3 d after weaning, and linoleic:linolenic acid ratio can impact gilt growth and the use of lower energy diets appears to reduce joint inflammation. In addition to grant funding, 22 additional projects were supported by in-kind industry donations/partnerships worth over $1.6 million. Resources generated are available in peer-reviewed publications, factsheets (English and Spanish), short informational videos, and podcasts (PigX). Project outcomes are available at the Improving Pig Surviability website (www.piglivability.org).

MEDIS—A comprehensive spatial database on Mediterranean islands for biogeographical and evolutionary research

AbstractMotivationThe intrinsic characteristics of islands make them a unique study system for the investigation of ecological and evolutionary dynamics. The Mediterranean Basin, an island‐rich biodiversity hotspot, still lacks a comprehensive spatial database for these geographic features. This study presents the first comprehensive spatial database of all Mediterranean islands larger than 0.01 km2, aiding ecological investigations and interdisciplinary research.Main types of variable containedThe MEDIS spatial database offers detailed information on 39 geographic, climatic, ecological and land‐use variables, including island area, perimeter, isolation metrics, climatic space, terrain data, land cover, palaeogeography, road networks and geological information, providing a multifaceted view of each island's characteristics.Spatial location and grainThe study encompasses 2217 islands in the Mediterranean Basin larger than 0.01 km2. The spatial grain of the datasets on which the selected variables are based varies from 10 m (ESA WorldCover) to 1 km (CHELSA‐BIOCLIM+).Time period and grainThe spatial database incorporates data from various sources, each with its own timeframe, such as the Global Shoreline Vector from 2014 Landsat imagery and the WorldCover dataset from 2021. Historical data like the Paleocoastlines GIS dataset offer insights into island configurations during the Last Glacial Maximum.Major taxa and level of measurementWhile not focusing on specific taxa, the study lays the foundation for comprehensive research on Mediterranean islands, facilitating comparisons and investigations into the distribution of native, endemic or alien species. The level of measurement is extensive, encompassing a wide range of variables and providing polygonal features rather than centroids' coordinates.

Examining the efficacy of inoculation and value‐affirmation interventions in improving precandidate reactions among prospective military recruits

AbstractThis study engaged 4848 first‐time, English‐speaking prospective Canadian Armed Forces applicants to evaluate pre‐application interventions' efficacy on the Practice Canadian Forces Aptitude Test (PCFAT). Using a five‐level between‐subjects design, participants were randomly assigned to one of the following intervention conditions: inoculation message, value‐affirmation message, a combination of both, placebo writing intervention, or a no‐intervention control group. The interventions were anchored in inoculation theory and value‐affirmation theory and aimed to reduce math anxiety and close the gender gap in test performance. Contrary to expectations, the interventions did not significantly reduce math anxiety or improve problem‐solving performance. Consistent with the literature, a negative relationship was found between levels of math anxiety and problem‐solving scores, and men outscored women in problem‐solving across all conditions. Despite these outcomes, the study lays a foundation for future research on enhancing pre‐applicant experiences in an increasingly competitive labor market. Implications and future directions are discussed.

Progress in the taxonomy of Late Cretaceous high-latitude radiolarians: insights from the Horton River area, Northwest Territories, Canada

Abstract. Radiolarians have proven to be exceptional tools in biostratigraphic and paleoenvironmental studies despite their relatively low preservation potential in the sedimentary record. Reports of Upper Cretaceous radiolarians in high northern latitudes are scant, and their taxonomy is not often discussed in the few reports available in the literature. In this study, we describe one new genus and three new species of polycystine radiolarians from Upper Cretaceous strata of the northern mainland coast of Arctic Canada. The specimens were recovered from the Santonian–middle Campanian Smoking Hills Formation and the middle Campanian–Maastrichtian Mason River Formation and are assigned to the genus Canadasphaera n. gen. (Order Spumellaria) and the species Canadasphaera inuita n. sp., Kuppelella rusti n. sp., and Lithocampe? rara n. sp. The taxonomic notes provided in this study improve our understanding of Late Cretaceous radiolarians from high northern latitudes and serve as a foundation for future Cretaceous radiolarian research in Arctic regions. Canadasphaera: urn:lsid:zoobank.org:act:C6B7B702-4B74-472D-8893-0A41B93A5066, date of registration: 19 April 2024 Canadasphaera inuita: urn:lsid:zoobank.org:act:C30E555B-EE94-4680-87D1-5CE83E128461, date of registration: 19 April 2024 Kuppelella rusti: urn:lsid:zoobank.org:act:68ECB628-2E74-4748-ACA4-DD1A33B05837, date of registration: 19 April 2024 Lithocampe? rara: urn:lsid:zoobank.org:act:25E569B2-93A8-425F-BB7C-D29A0437763F, date of registration: 19 April 2024

Applying spending review theory to developing countries: The case of South Africa

ABSTRACT The seminal spending review (SR) theoretical framework by Catalano & Erbacci [2018. A theoretical framework for spending review policies at a time of widespread recession. OECD Journal on Budgeting 17(2), 9–24] draws on the cutback management and related academic literature to articulate the first theory for explaining the ability of medium-term SRs conducted after the global financial crisis of 2008 to effect targeted savings. This literature is however dominated by advanced economies with sophisticated public financial management systems. Comparatively little attention, however, has been paid to theoretical perspectives on developing countries, like South Africa. This article applies this theoretical framework by Catalano and Erbacci to the South African SR initiative in order to interrogate its theoretical and empirical relevance. Proposals are made for enhancing the operationalisation of the organisational and process dimensions of C&E’s theoretical framework to lay a foundation for future empirical research and its policy implications for South Africans SRs are explored.

The Effect of Employee Involvement Participation in Directive Decision Making and its Impact on Employees Creativity: A Case Study of Higher Education in Oman

Purpose: The purpose of this study is to understand how the private higher education sector in Oman is adapting to global trends and industrial partnerships to prepare students for the workforce. Specifically, it aims to explore the relationship between employee involvement in participation, directorial decision-making, and employee innovation in this context, and how these factors contribute to differentiating institutions in a competitive environment.   Method: This study employs quantitative analysis to investigate the relationships between employee involvement, directed decision-making, and innovation within Oman's private higher education sector. Through the use of surveys and statistical methods, the study explores how directorial decision-making moderates the link between employee involvement and creativity.   Results and Conclusion:  The findings suggest that directorial decision-making plays a significant moderating role in the relationship between employee involvement and creativity. All proposed hypotheses were supported, indicating a positive correlation between employee participation in decision-making processes and innovation. These results underscore the importance of directorial strategies that encourage employee involvement as a catalyst for creativity within the sector.   Originality/Value: This study contributes uniquely to the body of knowledge on employee creativity in the private higher education industry by highlighting the critical role of leadership decision-making styles in fostering an innovative work environment. It provides empirical evidence supporting the need for policy reforms that encourage participative decision-making processes, thereby enhancing the sector's competitiveness and its ability to meet the demands of the global workforce. Through its insights, the study offers a foundation for further research and policy development aimed at nurturing innovation in higher education.

Characterization of Pediatric Infratentorial Arteriovenous Malformations: A Retrospective, Multicenter Cohort Study.

Infratentorial arteriovenous malformations (AVMs) harbor different characteristics compared with supratentorial AVMs. This study aims to explore the unique characteristics of pediatric infratentorial AVMs and their response to single session stereotactic radiosurgery (SRS). The International Radiosurgery Research Foundation database of pediatric patients with AVM (age <18 years) who underwent SRS was retrospectively reviewed. Baseline demographics, AVM characteristics, outcomes, and complications post-SRS were compared between infratentorial and supratentorial pediatric AVMs. Unfavorable outcome was defined as the absence of AVM obliteration, post-SRS hemorrhage, or permanent radiation-induced changes at last follow-up. A total of 535 pediatric AVMs managed with SRS with a median follow-up of 67 months (IQR 29.0-130.6) were included, with 69 being infratentorial and 466 supratentorial. The infratentorial group had a higher proportion of deep location (58.4% vs 30.3%, P = <.001), deep venous drainage (79.8% vs 61.8%, P = .004), and prior embolization (26.1% vs 15.7%, P = .032). There was a higher proportion of hemorrhagic presentation in the infratentorial group (79.7% vs 71.3%, P = .146). There was no statistically significant difference in the odds of an unfavorable outcome (odds ratio [OR] = 1.36 [0.82-2.28]), AVM obliteration (OR = 0.85 [0.5-1.43]), post-SRS hemorrhage (OR = 0.83 [0.31-2.18]), or radiologic radiation-induced changes (OR = 1.08 [0.63-1.84]) between both cohorts. No statistically significant difference on the rates of outcomes of interest and complications were found in the adjusted model. Despite baseline differences between infratentorial and supratentorial pediatric AVMs, SRS outcomes, including AVM obliteration and post-SRS hemorrhage rates, were comparable amongst both groups. SRS appears to have a similar risk profile and therapeutic benefit to infratentorial pediatric AVMs as it does for those with a supratentorial location.

Abstract PO2-02-14: Development of a multi-institutional, photograph-rich clinical dataset to test and validate a novel inflammatory breast cancer (IBC) scoring system

Abstract Purpose: Susan G. Komen, The Inflammatory Breast Cancer (IBC) Research Foundation, and the Milburn Foundation convened a collaborative of patient advocates, clinicians, and researchers and proposed a novel quantitative scoring system for IBC diagnosis. The score includes timing of symptoms, extent of skin edema and erythema/other discoloration, breast and nipple asymmetry, lympho-vascular space invasion, nodal stage, and diffuse extent disease in the breast on breast imaging. Total scores were categorized (&amp;lt; 14 Not IBC, 14-24 Weak Possibility of IBC, 25-41 Strong Possibility of IBC, &amp;gt; 41 Definitely IBC). Herein, we developed a multi-institutional clinical dataset to retrospectively test and validate the proposed scoring system. Methods: IBC (N= 988) and non-IBC (N=322) cases were identified at two institutions with dedicated multi-disciplinary IBC programs, UT MD Anderson Cancer Center (MDA) and Dana-Farber Cancer Institute (DFCI). The DFCI cohort was diagnosed from 1986-2021 and the MDA cohort was diagnosed from 2010-2020. The non-IBC cohorts were identified as consecutive T4b and T4c cases in existing retrospective databases. Photographs were reviewed for available cases. All scoring variables were reviewed with data extractors and standard operating procedures (SOPs) developed for all ambiguous findings and language. A subset of scores were reviewed by IBC clinicians (FL, WW) and discrepancies discussed to inform the SOPs. Missing data imputation using three methods was examined. Area under the curve (AUC) - Receiver operator characteristic (ROC) curves and values, and sensitivity and specificity for the proposed score cut offs were examined. Results: Of 1320 patients currently in the analysis, 421 (31.9%) have missing data on &amp;gt; 1 characteristics and 47 (3.6%) are missing data on &amp;gt; 4. The rubric characteristic most commonly missing was “nipple abnormalities” accounting for 21.0% and 19.3% for IBC and non-IBC cohorts respectively. Unavailable bilateral breast photograph was the primary source of missing data. The highest scoring finding was present in the following percentage of IBC and non-IBC cases, respectively: timing of symptom onset &amp;lt; 3 months (74.1% vs 38.6%), any peau d’orange (61.2% vs 30.1%), clinically apparent enlargement or new asymmetry of breast size (87.8% vs 90.1%), complete or near complete involvement of the breast skin by erythema or discoloration (55.6% vs 25.6%), new nipple inversion (24.6% vs 9.0%), dermal lymphovascular emboli present (17.9% vs 1.8%), diffuse involvement of the breast parenchyma by imaging (72% vs 77.7%). True IBC cases were categorized as Definitely IBC, Strong Possibility, Weak Possibility, not IBC and unknown 19.7%, 49.1%, 0.4%, 0.1%, and 30.7%. True non-IBC were 0.6%, 51.8%, 9.9%, 2.1%, and 35.5%. Random imputation, lowest value imputation, and median value imputation were compared to impute missing data. AUC-ROC values for each method were similar, 0.80 - 0.84. Conclusion: We describe the development of the largest multi-institutional IBC clinical database to date. SOPs for the rubric characteristics were developed. The importance of bilateral photography to assess the score retrospectively is highlighted. The score is associated with a good AUC-ROC but still leaves much overlap among cases between 25 and 42. Further optimization of the current scoring system and association with outcomes are in progress. Citation Format: Filipa Lynce, Samuel Niman, Megumi Kai, Sean Ryan, Elizabeth Troll, Li Li, Kathy Miller, Reshma Jagsi, Ginny Mason, Beth Overmoyer, H. T. Carisa Le-Petross, Faina Nakhlis, Savitri Krishnamurthy, Beth Harrison, Susie X. Sun, Eren Yeh, Jennifer Bellon, Laura Warren, Michael Stauder, Meredith Regan, Wendy Woodward. Development of a multi-institutional, photograph-rich clinical dataset to test and validate a novel inflammatory breast cancer (IBC) scoring system [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO2-02-14.

Identification of Phytophthora cinnamomi CRN effectors and their roles in manipulating cell death during Persea americana infection

The oomycete Phytophthora cinnamomi is a devastating plant pathogen with a notably broad host range. It is the causal agent of Phytophthora root rot (PRR), arguably the most economically important yield-limiting disease in Persea americana (avocado). Despite this, our understanding of the mechanisms P. cinnamomi employs to infect and successfully colonize avocado remains limited, particularly regarding the pathogen’s ability to maintain its biotrophic and necrotrophic lifestyles during infection. The pathogen utilises a large repertoire of effector proteins which function in facilitating and establishing disease in susceptible host plants. Crinkling and necrosis effectors (CRN/Crinklers) are suspected to manipulate cell death to aid in maintenance of the pathogens biotrophic and necrotrophic lifestyles during different stages of infection. The current study identified 25 P. cinnamomi CRN effectors from the GKB4 genome using an HMM profile and assigned putative function to them as either cell death inducers or suppressors. Function was assigned to 10 PcinCRNs by analysing their RNA-seq expression profiles, relatedness to other functionally characterised Phytophthora CRNs and tertiary protein predictions. The full-length coding sequences for these PcinCRNs were confirmed by Sanger sequencing, six of which were found to have two divergent alleles. The presence of alleles indicates that the proteins encoded may perform contradicting functions in cell death manipulation, or function in different host plant species. Overall, this study provides a foundation for future research on P. cinnamomi infection and cell death manipulation mechanisms.

Regulatory Issues in Electronic Health Records for Adolescent HIV Research: Strategies and Lessons Learned.

Electronic health records (EHRs) are a cost-effective approach to provide the necessary foundations for clinical trial research. The ability to use EHRs in real-world clinical settings allows for pragmatic approaches to intervention studies with the emerging adult HIV population within these settings; however, the regulatory components related to the use of EHR data in multisite clinical trials poses unique challenges that researchers may find themselves unprepared to address, which may result in delays in study implementation and adversely impact study timelines, and risk noncompliance with established guidance. As part of the larger Adolescent Trials Network (ATN) for HIV/AIDS Interventions Protocol 162b (ATN 162b) study that evaluated clinical-level outcomes of an intervention including HIV treatment and pre-exposure prophylaxis services to improve retention within the emerging adult HIV population, the objective of this study is to highlight the regulatory process and challenges in the implementation of a multisite pragmatic trial using EHRs to assist future researchers conducting similar studies in navigating the often time-consuming regulatory process and ensure compliance with adherence to study timelines and compliance with institutional and sponsor guidelines. Eight sites were engaged in research activities, with 4 sites selected from participant recruitment venues as part of the ATN, who participated in the intervention and data extraction activities, and an additional 4 sites were engaged in data management and analysis. The ATN 162b protocol team worked with site personnel to establish the necessary regulatory infrastructure to collect EHR data to evaluate retention in care and viral suppression, as well as para-data on the intervention component to assess the feasibility and acceptability of the mobile health intervention. Methods to develop this infrastructure included site-specific training activities and the development of both institutional reliance and data use agreements. Due to variations in site-specific activities, and the associated regulatory implications, the study team used a phased approach with the data extraction sites as phase 1 and intervention sites as phase 2. This phased approach was intended to address the unique regulatory needs of all participating sites to ensure that all sites were properly onboarded and all regulatory components were in place. Across all sites, the regulatory process spanned 6 months for the 4 data extraction and intervention sites, and up to 10 months for the data management and analysis sites. The process for engaging in multisite clinical trial studies using EHR data is a multistep, collaborative effort that requires proper advanced planning from the proposal stage to adequately implement the necessary training and infrastructure. Planning, training, and understanding the various regulatory aspects, including the necessity of data use agreements, reliance agreements, external institutional review board review, and engagement with clinical sites, are foremost considerations to ensure successful implementation and adherence to pragmatic trial timelines and outcomes.